The manuscript titled “Proteome analysis of secretions from human monocyte-derived macrophages post-exposure to biomaterials and the effect of secretions on cardiac fibroblast fibrotic character” has been accepted in Acta Biomaterialia (In press, 2020). This study demonstrates that human blood-derived macrophages cultured on D-PHI expressed significantly higher levels of AGRN, TGFBI and ANXA5 but lower levels of MMP7, IL-1b, IL-6 and TNFa when compared to macrophages cultured on a well-established degradable biomaterials in the medical field, e.g. PLGA and TCPS, which are often used as the relative standards for cell culture work in the biomaterials field. In another aspect of the work, human cardiac fibroblasts showed significantly lower contractility when cultured in presence of macrophage secretions collected after culturing them on D-PHI compared to PLGA and TCPS. The findings place emphasis on the importance of making the choice of biomaterials for tissue engineering and regenerative medicine applied to their use in cardiac tissue repair.